Wildfires can dramatically alter water quality, resulting in severe implications for human and freshwater systems. However, regional-scale assessments of these impacts are often limited by data scarcity. Here, we unify observations from 1984–2021 in 245 burned watersheds across the western United States, comparing post-fire signals to baseline levels from 293 unburned basins. … Overall, this analysis provides strong evidence of multi-year water quality degradation following wildfires in the western United States and highlights the influence of basin and wildfire features. These insights may aid water managers in preparation efforts, increasing resilience of water systems to wildfire impacts.